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National Open University Exam Past Question – CHM 421 OCTOBER/NOVEMBER 2014 EXAMINATION

NATIONAL OPEN UNIVERSITY OF NIGERIA CHM 421 HETEROCYCLIC CHEMISTRY

14-16 AHMADU BELLO WAY, VICTORIA ISLAND LAGOS SCHOOL OF SCIENCE AND TECHNOLOGY OCTOBER/NOVEMBER 2014 EXAMINATION

 

 

COURSE CODE: CHM 421                                                                                        DURATION: 2 HOURS

 

TITLE: HETEROCYCLIC CHEMISTRY                                                                          CREDIT UNIT: 2

 

INSTRUCTION: ANSWER ANY FOUR QUESTIONS

 

 

 

  1. 1. (a) Write short notes on the uses of Chloroquin (6mks)

(b) Outline the synthesis of Nicotinic acid from Quinoline.                                        (11 ½ mks)

 

 

  1. 2. (a) With the aid of a reaction scheme, show how Indole reacts with triethylorthoformate

(triethoxymethane).                                                                                                      (13 ½ mks) (b) State the physical and chemical properties of indole.                                                  (4mks)

 

 

 

  1. 3. Describe the Conrad-Limpach Synthesis of Quinolin  (17 ½ mks) (show the reaction scheme)

 

 

  1. 4. (a) Highlight the general physical properties of Quinolin                                               (4mks)

(b) Show schematically Quinoline’s reaction with fuming Nitric acid in concentrated

Sulphuric acid.                                                                                                                  (13 ½ mks)

 

 

 

  1. 5. Write the chemical structure of the following compounds:
(i) Dimethisoquine (5mks)
(ii) Papaverine (5mks)
(iii) Naphthalene (2 ½ mks)
(iv) N-laurylisoquinolium Bromide (5mks)

 

 

 

  1. 6. (a) Indole is known to undergo certain reactions, one of which is reduction. Explain this reaction as it relates to indole and show the reaction mechanism.                      (15 ½ mks)
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(b) Mention two applications of indole (2mks)

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